Educational lecture on hemopoietic stem cells.
نویسندگان
چکیده
منابع مشابه
Hemopoietic Stem and Progenitor Cells
Pluripotent hemopoietic stem cells (PHSC) 1 are operationally defined by their ability to generate all of the cellular components of the lymphohemopoietic system while retaining the capacity for extensive self-replication. The existence of PHSC has been documented by the in vivo spleen colony-forming unit (CFU-S) assay (1) and by cell tracer studies (2, 3). The major obstacles to the isolation ...
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Two key properties of hemopoietic stem cells are their capacity for selfrenewal and their capacity for differentiation. The stem ceils in mouse hemopoietic tissues that may be detected by their ability to form macroscopic splenic colonies possess both these properties, but express them to widely varying degrees. For example, colonies derived from single stem cells may differ greatly in their co...
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The causes of anemia and immunosuppression, major outcomes of malaria, are not well established. This study was undertaken to investigate whether erythropoietin (EP) production is adequate and whether the hemopoietic stem cells (CFU-S) were affected during the course of infection. Groups of female Balb/c mice infected with Plasmodium vinckei vinckei, Plasmodium berghei, or Plasmodium chabaudi a...
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A method described to purify pluripotent hemopoietic stem cells ( PHSC ) from adult mouse bone marrow. The method consists of three separation steps. First, bone marrow cells are centrifuged in a discontinuous metrizamide gradient and simultaneously labeled with wheat germ agglutinin-fluorescein isothiocyanate (WGA-FITC). Second, the low density cells are analyzed by a fluorescence-activated ce...
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ژورنال
عنوان ژورنال: Nihon Naika Gakkai Zasshi
سال: 1989
ISSN: 0021-5384,1883-2083
DOI: 10.2169/naika.78.1721